Scientist- Delivery Sciences-targeted LNPs (tLNPs)
Core
Design, formulate, and characterize targeted Lipid Nanoparticles (tLNPs) with antibody conjugates to deliver nucleic acid payloads into non-liver cells and tissues.
Role type
Senior IC formulation scientist (tLNP platform)
Builds
Targeted LNP platform for extra-hepatic delivery
Domain
Biotechnology / Lipid Nanoparticle delivery / Epigenome reprogramming
Required skills
tLNP design and formulation, conjugation chemistry (antibodies, nanobodies, scFv), SAR-driven design, purification (HPLC, SEC), analytical characterization (DLS, LC-CAD, SPR)
Preferred skills
Scale-up process development, CMC, tech transfer, data visualization (R, Python)
Technologies
HPLC, DLS, LC-CAD, CE, bio-layer interferometry, surface plasmon resonance
Responsibilities
Design and develop LNP compositions and conjugation chemistries; Plan conjugation reactions and purification; Test targeting lipids using SAR-based approach; Develop in-house or partner conjugation processes; Optimize tLNP compositions based on in vitro/in vivo data; Author technical reports and protocols
Seniority
Senior, hands-on IC
