Scientist I, mRNA, Process Development
Core
Design, execute, and optimize mRNA production and purification processes to achieve desired yields and purity for mRNA-based therapeutics.
Role type
Senior IC process development scientist (mRNA)
Builds
mRNA drug substance for partners and external clients
Domain
Biopharmaceutical manufacturing / mRNA therapeutics
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
mRNA synthesis, purification, and characterization; in-vitro transcription (IVT) and plasmid DNA linearization; Tangential Flow Filtration (TFF); chromatography (dT Affinity, IEX, RP-HPLC); automated chromatography systems (ÄKTA Avant/Pure); filtration skids (Repligen KrosFlow Kr2i); process scaling from bench to GMP; tech transfer activities
Preferred skills
mRNA-LNP formulation and mixing technologies; statistical software (JMP) for Design of Experiments (DoE); GMP regulations and Quality by Design principles; regulatory filing documentation
Responsibilities
Lead development, optimization, and scale-up experiments for mRNA processes; characterize mRNA samples using analytical techniques (electrophoresis, spectrophotometry, HPLC/UPLC); support tech transfer of mRNA-based therapeutics; create SOWs and proposals for external clients; communicate experimental results to stakeholders and clients; develop SOPs and technical documents
Seniority
Senior, hands-on IC