Senior Associate Scientist, Purification, RNA Process Development
Core
Designing efficient, robust, and scalable manufacturing processes for RNA drug substances (circular and linear mRNA modalities) through hands-on experimental execution and process characterization.
Role type
Senior Associate Scientist, RNA Process Development
Builds
RNA drug substance purification processes for clinical manufacturing
Domain
Biopharmaceuticals / mRNA therapeutics
Required skills
Chromatography, Filtration (TFF/UF-DF), Statistical Design of Experiments (DoE), Process Analytics, Biophysical Characterization (HPLC, CE, Gel Electrophoresis), cGMP/QbD principles
Preferred skills
Nucleic acid chemistry, Lipid chemistry, Scale-down modeling, Mechanistic modeling, Clinical manufacturing support
Technologies
HPLC, CE, Gel Electrophoresis, TFF, UF-DF
Responsibilities
Execute and analyze experiments for existing and novel process modes, Support RNA drug substance purification process definition and scale up, Experiment using high throughput/automated or data rich experimental setups, Support experiments to confirm robust process performance across the control space, Collaborate with analytical teams to enable deeper characterization of RNA properties and impurity profiles, Collaborate closely with upstream PD to characterize IVT feed stream to maximize RNA yield and purity
Seniority
Senior, hands-on IC
