Scientist, Process Development
Core
Design, execute, and optimize mRNA synthesis, purification, and characterization processes to support tech transfer and manufacturing of mRNA-based therapeutics.
Role type
Senior IC process development scientist (mRNA)
Builds
mRNA drug substance at bench scale and GMP manufacturing scale
Domain
Biopharmaceuticals / mRNA therapeutics
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
mRNA synthesis (IVT), plasmid DNA linearization, TFF, chromatography (dT Affinity, IEX, RP-HPLC), automated chromatography systems, filtration skids, process scaling, tech transfer
Preferred skills
mRNA-LNP formulation, statistical software (JMP) for DoE, GMP regulations, Quality by Design, regulatory filing documentation
Technologies
ÄKTA Avant/Pure, Repligen KrosFlow Kr2i, HPLC/UPLC, electrophoresis, spectrophotometry
Responsibilities
Lead development, optimization, and scale-up experiments for mRNA processes; characterize mRNA samples using analytical techniques; support tech transfer activities; contribute to SOP development
Seniority
Senior, hands-on IC