Scientist, Bioconjugation & Targeted RNA Delivery
Core
Design, synthesis, purification, and characterization of ligand-oligonucleotide conjugates (LOCs) for targeted extrahepatic RNA delivery to tissues like muscle, adipose, and ocular compartments.
Role type
Senior IC medicinal/organic chemist (bioconjugation & RNA delivery)
Builds
Novel ligand-oligonucleotide conjugates for nucleic acid medicines
Domain
Biopharmaceuticals / RNA therapeutics / Chemical Biology
Required skills
bioconjugation chemistry, click chemistry, lysine/cysteine coupling, enzymatic ligation, stimuli-sensitive linker technologies, preparative RP-HPLC, affinity chromatography, IEX, HIC, SEC, TFF, LC-MS, LC-HRMS, CE-SDS, DSC, NMR, analytical workflow development
Preferred skills
CRO management, cross-functional drug discovery program experience, patent/IP generation, IND-related activities
Technologies
Click chemistry, enzymatic ligation, LC-MS, LC-HRMS, CE-SDS, DSC, NMR, RP-HPLC, TFF
Responsibilities
Design and execute bioconjugation strategies for ligand-oligonucleotide conjugates; Perform hands-on synthesis, purification, and analytical characterization; Develop and optimize conjugation chemistries and linker strategies; Work cross-functionally to evaluate candidates in vitro and in vivo; Coordinate with external CROs and suppliers; Maintain experimental reproducibility and scientific documentation; Contribute to intellectual property and publications; Present scientific findings and contribute to project decision-making
Seniority
Mid-Senior, hands-on IC