Senior Bioprocess Engineer II, MSAT, Proteins
Core
Lead microbial manufacturing operations for vaccine polysaccharide intermediates from commercial readiness through PPQ and ongoing production at CMOs.
Role type
Senior Bioprocess Engineer (Microbial Fermentation & Purification)
Builds
Polysaccharide intermediates for Vaxcyte's vaccine portfolio
Domain
Biopharmaceuticals / Vaccine Manufacturing
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
microbial fermentation, primary recovery, purification (chromatography, UF/DF), GMP compliance, process validation, technology transfer, CAPA management, FMEA, troubleshooting, project management
Preferred skills
vaccine manufacturing experience, drug substance manufacturing equipment qualification, cell-free upstream technology, facility fit assessment, scale-down studies, DOE implementation
Technologies
bioreactor systems, process analytics/control systems, homogenization/microfluidization, centrifugation, depth filtration, precipitation
Responsibilities
Manage complex microbial manufacturing processes for vaccine intermediates; oversee CMO service providers for commercial campaigns; lead process investigations and CAPAs; drive continuous improvement and change management; support CMO inspections and regulatory follow-up; author technical reports and regulatory submissions.
Seniority
Senior, hands-on IC with technical leadership