Scientist

Axle Informatics LLCFull-time$105k–$115k2026-10-29 → 2026-11-10

On-site

Core

Develop and optimize downstream processes for recombinant proteins, mRNA, and virus-like particles to support clinical trial vaccine candidates and therapeutic development.

Role type

Senior Scientist (Bioprocessing/Downstream Development)

Builds

Clinical-grade recombinant proteins, mRNA, and virus-like particles for vaccine and therapeutic candidates

Domain

Biotechnology / Biopharmaceuticals / Vaccine Development

Required skills

Recombinant protein process development, Chromatography (AEX, CEX, affinity, SEC, HIC), Tangential Flow Filtration (TFF), Normal Flow Filtration (NFF), mRNA in vitro transcription (IVT), Design of Experiments (DoE), Viral clearance validation, GMP compliance, SDS-PAGE, Western Blot

Preferred skills

Experience with mRNA-LNP encapsulation, Technology transfer to pilot plant, CMC documentation, Statistical analysis

Technologies

AKTA chromatography systems, Lab scale TFF/NFF systems, UV/vis spectrophotometer

Responsibilities

Design and optimize purification processes for clinical trial candidates; Support viral clearance validation studies; Write and review CMC sections of IND filings; Train associate scientists on chromatography and filtration; Present research findings at scientific meetings; Coordinate with cross-functional teams for project goals.

Seniority

Senior, hands-on IC

About Axle

Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH)