Principal Scientist--Pharmacokinetics, Dynamics and Metabolism
Core
Lead enzymology studies and ADME risk assessments to guide small molecule discovery and development decisions.
Role type
Principal Scientist, Pharmacokinetics, Dynamics and Metabolism
Builds
Evidence-based recommendations for project progression and risk mitigation
Domain
Pharmaceutical R&D, ADME Sciences
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
enzymology, drug metabolism principles, in vitro-to-in vivo translation, DDI risk assessment, experimental design, data interpretation, scientific communication, mentoring
Preferred skills
PBPK modeling, transporter science, biotransformation, long-term culture systems, assay improvement, AI tool utilization
Technologies
Microsoft Copilot
Responsibilities
Design and execute enzymology studies; integrate in vitro ADME data to identify liabilities; lead ADME risk assessments; mentor scientists; identify capability gaps and propose novel approaches
Seniority
Principal, hands-on IC with mentorship
