PhD Student- GATES
Core
Investigate how mutations in mitochondrial genes (MT-CO1, MT-CO2, MT-CO3) contribute to chemoresistance in acute myeloid leukaemia by characterizing mitochondrial Complex IV structure and function.
Role type
PhD Student (Structural Biology & Molecular Biology)
Builds
Mechanistic model linking mitochondrial Complex IV remodelling to altered mitochondrial homeostasis and reduced cytarabine sensitivity.
Domain
Oncology / Structural Biology / Mitochondrial Biology
Deliverable
research
Required skills
Molecular biology, Structural biology, Bioinformatics
Preferred skills
RNA-seq analysis, Mitochondrial phenotyping, Cryo-EM, SAXS
Technologies
Cryo-EM, SAXS, RNA-seq
Responsibilities
Perform structural characterization of Complex IV using SAXS and cryo-EM; Examine transcriptomic and functional impact of mutations via RNA-seq and phenotyping; Integrate structural, transcriptomic, and functional data to build a mechanistic model.
Seniority
PhD Student