Postdoctoral Fellow, Multiple Myeloma Immuno-Oncology, Oncology Bioscience
Core
Characterize the mechanism of a first-in-class kinase inhibitor in multiple myeloma by identifying innate immune cell types and evaluating combination strategies with T-cell therapies.
Role type
Postdoctoral Fellow (Preclinical Oncology/Immunology)
Builds
Preclinical discovery program for a novel kinase inhibitor
Domain
Oncology / Immunology / Multiple Myeloma
Deliverable
research
Required skills
In vivo mouse models, CRISPR-based models, flow cytometry, single-cell RNA-seq, CyTOF, CITE-seq, western blot, ELISA, cell-based functional assays
Preferred skills
Xenograft mouse models, immune cell depletion/reconstitution, innate immune biology (NK cells, macrophages)
Responsibilities
Lead in vivo studies in syngeneic and xenograft mouse models; Dissect mechanistic contribution of innate immune cell types; Apply advanced immunophenotyping and transcriptomic platforms; Evaluate rational combination strategies with T-cell engagers and CAR-T therapies; Drive a clear publication plan
Seniority
Postdoctoral Fellow