Principal Research Scientist I, Process Chemistry (Biocatalysis)
Core
Developing biocatalytic processes for the scalable synthesis of active pharmaceutical ingredients (APIs) including small molecules, peptides, and antibody-drug conjugates.
Role type
Principal Research Scientist I, Process Chemistry (Biocatalysis)
Builds
Scalable chemical manufacturing processes for pre-clinical and clinical drug candidates
Domain
Pharmaceutical process chemistry / Biocatalysis
Deliverable
production ML models | product features
Required skills
Biocatalysis expertise, Synthetic organic chemistry, Recombinant DNA techniques, Protein expression, Directed evolution, High-throughput experimentation (HTE), AI/ML for chemical synthesis, Process development
Preferred skills
Innovation in chemical and automation technologies, Scientific leadership
Technologies
AI/ML tools, Bioinformatics platforms, HTE platforms
Responsibilities
Set and implement strategies for solving complex synthetic problems via biocatalytic methods; Identify and design enzymes and engineer biocatalysts with improved activity/selectivity/stability; Leverage AI/ML and HTE to accelerate enzyme screening and optimization; Lead project teams for process development and characterization; Author technical reports, patents, and scientific publications.
Seniority
Principal, hands-on IC with strategic oversight