Principal Research Scientist I Eng
Core
Design and develop scalable manufacturing processes for drug substances and products (small molecules, ADCs, biologics) from lab to pilot/production scale.
Role type
Principal Research Scientist I Eng (Process Engineering)
Builds
Robust manufacturing processes, novel engineering technologies, and regulatory-ready CMC content.
Domain
Pharmaceutical manufacturing / Chemical Engineering / CMC (Chemistry, Manufacturing, and Controls)
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Reaction development, scale-up, process definition, tech transfer, reaction kinetics, transport phenomena, mathematical modeling, process analytical technologies, model-guided experimentation, regulatory filing preparation, cross-functional leadership
Preferred skills
Experience with antibody drug conjugates (ADCs), lipid nanoparticles (LNPs), toxins, or cosmetic active ingredients (CAIs)
Technologies
Pilot plant equipment, data-rich experimentation tools, process analytical technologies
Responsibilities
Develop robust manufacturing processes supporting assets through all phases of development; Participate in and/or lead project teams for new small and large molecule assets; Establish and execute research plans; Demonstrate processes in pilot plant; Address challenging problems with chemical/biochemical reactions and separations; Author and review technical documents for regulatory filings; Lead cross-functional teams to solve process challenges.
Seniority
Principal, hands-on IC with strategic project leadership
