Senior Scientist l, QTAS & ADME Sciences
Core
Lead in vitro ADME science and quantitative modeling to advance drug candidates from early to late stages.
Role type
Senior Scientist, Quantitative, Translation & ADME Sciences
Builds
Translational mechanistic models and global in vitro ADME strategy
Domain
Pharmaceutical R&D, Drug Metabolism and Pharmacokinetics (DMPK)
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
cell culture methods (hepatocytes, cell lines), drug metabolism principles, enzyme kinetics, IVIVE, DDI risk assessment, in vitro assay design, quantitative bioanalysis, translational modeling concepts
Preferred skills
drug permeability and transport, receptor pharmacology, pharmacokinetic modeling, novel in vitro tool evaluation
Technologies
in vitro models, cellular and subcellular models
Responsibilities
Conduct and lead in vitro assays in cellular and subcellular models; Evaluate and apply novel in vitro tools to predict human PK and DDI potential; Liaise with discovery biology/pharmacology to build translational models; Communicate findings on in vitro drug metabolism; Maintain expertise in emerging modeling literature
Seniority
Senior, hands-on IC with leadership competencies