Senior Principal Scientist -Bioanalytical Assay- Cell Therapy
Core
Define and drive bioanalytical strategy to characterize the in vivo fate of therapeutic cells (expansion, persistence, trafficking, biodistribution, phenotypic evolution, immunogenicity) and inform development, regulatory, and portfolio decisions for cell therapy products.
Role type
Senior Principal Scientist (Bioanalytical Strategy, Cell Therapy)
Builds
Integrated bioanalytical strategies and evidence generation plans for cell therapy development programs
Domain
Biopharmaceuticals / Cell Therapy / Bioanalytical Sciences
Required skills
Bioanalytical strategy definition, Cell therapy product development expertise, In vivo cell fate characterization, Flow cytometry, Molecular assays (qPCR/ddPCR), Ligand-binding assays, Functional bioassays, Biomarker assays, Multiomic approaches, Cross-functional scientific leadership, Strategic partnership building, Scientific standardization
Preferred skills
Data integration across translational/clinical/computational/manufacturing domains, Harmonized assay strategies across programs, AI-enabled bioanalytical data interpretation
Technologies
Flow cytometry, qPCR, ddPCR, Ligand-binding assays, Functional bioassays, Biomarker assays, Multiomic platforms
Responsibilities
Define bioanalytical strategies for cell therapy portfolios, Identify and prioritize scientific questions on cell fate and immunogenicity, Partner with project leads to develop fit-for-purpose analytical approaches, Build strategic partnerships across R&D functions, Harmonize scientific approaches and establish best practices, Drive consistency in bioanalytical strategy, Integrate multi-disciplinary insights for development decisions, Translate emerging scientific questions into evidence-generation strategies, Evaluate and incorporate innovative bioanalytical approaches, Represent Bioanalytical Sciences on governance teams, Mentor scientists and foster scientific excellence
Seniority
Principal, strategy & mentorship