Senior Scientist / Principal Scientist, Complex in Vitro Systems
Core
Developing, characterizing, and qualifying advanced complex in vitro models (specifically human iPSC-derived ocular models like retinal organoids) to support drug development, target assessment, and safety evaluation.
Role type
Senior/Principal Scientist, Complex in Vitro Systems (Ocular)
Builds
Human iPSC-derived ocular complex in vitro models (CIVM) including retinal organoids and RPE co-culture platforms
Domain
Biopharmaceuticals / Ophthalmology / Regenerative Medicine
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
3D ocular tissue model development, retinal organoid culture, co-culture system design, confocal microscopy, high-content imaging, qRT-PCR, scRNA-seq, proteomics, transcriptomics, data analysis, SOP writing
Preferred skills
Stem cell-based systems expertise, ophthalmology background, cell engineering, Design of Experiments (DOE), computational data analysis
Technologies
iPSC, retinal organoids, RPE, confocal microscopy, high-content imaging, qRT-PCR, scRNA-seq, proteomics
Responsibilities
Culturing and characterizing state-of-the-art ocular CIVM models, designing and executing model qualification studies (imaging, transcriptomics, functional assays), analyzing complex datasets, collaborating with cross-functional teams on therapeutic strategies, maintaining electronic documentation per SOPs
Seniority
Senior (0-4 years post-PhD) / Principal (5+ years post-PhD)
