Postdoctoral Fellow - Cell Line Development, Lu & Ng Labs
Core
Developing a HEK293 'Super-Host' platform to overcome biological bottlenecks in recombinant Adeno-Associated Virus (rAAV) production for gene therapy applications.
Role type
Postdoctoral Fellow, Cell Line Development
Builds
HEK293 host cell lines optimized for high-yield rAAV manufacturing
Domain
Biotechnology / Gene Therapy / Cell Line Engineering
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
molecular biology, cell biology, biochemistry, virology, genetic engineering, CRISPR/Cas9, multi-omics platforms, independent research, scientific writing
Preferred skills
mammalian cell culture (HEK293), stable cell line generation, systems biology technologies, rAAV production and characterization
Technologies
CRISPR/Cas9, transposon-mediated systems, genomics, transcriptomics, proteomics, metabolomics, mass photometry, long-read sequencing
Responsibilities
Identify and overcome cellular bottlenecks restricting viral yields, systematically modify HEK293 hosts to tolerate intensive viral replication, collaborate with researchers across drug development teams, contribute to scientific publications
Seniority
Postdoctoral Fellow, early career scientist
