Senior Scientist, Spatial Assays
Core
Lead strategy, design, development, and lifecycle management of tissue-based biomarker assays (IHC, ISH, mIF, spatial/digital pathology) to support translational research and clinical development of engineered cell-based therapies.
Role type
Senior Scientist, Spatial Assays (Translational Research)
Builds
Tissue-based biomarker assays and spatial pathology platforms for cell therapy programs
Domain
Oncology / Immunology / Cell Therapy / Spatial Biology
Required skills
Spatial assay development, IHC, ISH, multiplex immunofluorescence, image analysis, assay validation, CRO management, project management, tissue processing, biomarker data interpretation
Preferred skills
Ph.D. in Pathology/Immunology/Cancer Biology, experience with CosMx/COMET/GeoMx/RNAscope platforms, oncology/immunology therapeutic area knowledge
Technologies
CosMx, COMET, GeoMx, RNAscope, Akoya, 10xgenomics, digital pathology platforms
Responsibilities
Lead assay feasibility studies and antibody characterization; serve as SME for external lab partnerships and CROs; establish assay performance criteria and quality control measures; partner with translational scientists on biomarker strategies; interpret and communicate validation data to governance committees; manage vendor relationships and budgets; drive innovation in spatial imaging technologies
Seniority
Senior, hands-on IC