Process Development Scientist - Torrance
Core
Design, execute, optimize, and scale-up synthetic processes for peptide and/or oligonucleotide API development, bridging lab development to cGMP-compliant manufacturing.
Role type
Process Development Scientist (Peptide/Oligonucleotide Chemistry)
Builds
Synthetic processes and purified APIs for clinical and commercial manufacturing
Domain
Pharmaceutical manufacturing, peptide chemistry, organic synthesis
Required skills
synthetic organic chemistry, process development, analytical techniques, peptide chemistry, downstream purification, HPLC, lyophilization, technology transfer, cGMP compliance
Preferred skills
oligonucleotide chemistry, scale-up, regulated manufacturing environment experience
Technologies
HPLC, lyophilization, reactor systems
Responsibilities
Plan and coordinate technology transfer activities from Development to Production; Design, execute, and optimize synthetic processes for peptide and/or oligonucleotide API development; Perform intermediate chemical processing steps using established safety and process procedures; Check reactor systems for proper operation in accordance with SOPs and operating manuals; Monitor chemical reactions during processing and respond appropriately to ensure proper execution; Prepare solutions for purification; Interpret test results and take appropriate action to support acceptable processing; Purify crude peptide using HPLC under minimal supervision; Conduct lyophilization and drying processes according to established procedures; Perform in-process checks of fractions using analytical HPLC and report results to supervision or senior development personnel; Support troubleshooting of equipment and processing issues; Identify and report deviations, equipment concerns, or unresolved processing issues; Maintain high standards for safety, housekeeping, and cleanliness; Support cross-functional project teams with technical expertise
Seniority
Mid-level, hands-on IC
