Scientist / Senior Scientist Translational Biology
Core
Lead preclinical mechanism-of-action work for clinical-stage complement inhibitor and lipid-modulating agent programs to slow retinal cell death and vision loss.
Role type
Senior Scientist, Translational Biology (hands-on IC)
Builds
In vitro cell models and readouts connecting clinical biomarkers to drug mechanism; in vivo pharmacology and PK/PD studies
Domain
Biopharmaceuticals / Ophthalmology / Translational Biology
Required skills
Mammalian cell culture, quantitative functional assays (immunoassays, flow cytometry, high content imaging, qPCR), cell-based assay qualification, quantitative data analysis, experimental design and troubleshooting, in vivo study management with CROs
Preferred skills
Gene-therapy construct evaluation (AAV), protein-engineered variants, complement biology, lipid trafficking, ocular diseases
Technologies
iPSC-derived RPE, microglia, retinal and endothelial models, AAV, flow cytometry, high content imaging
Responsibilities
Design and execute in vitro studies to extend mechanism of action; Evaluate next-generation forms and delivery approaches; Build in vitro biology connecting clinical biomarkers to drug mechanism; Assess new disease applications for existing mechanisms; Collaboratively design and manage in vivo pharmacology and PK/PD studies with CROs; Present data and recommendations at internal and external meetings
Seniority
Senior, hands-on IC