Director, In Vivo Pharmacology and Disease Biology
Core
Lead the In Vivo Pharmacology and Disease Biology function to design, validate, and execute animal models for ultra-long-acting obesity and cardiometabolic therapies.
Role type
Director, In Vivo Pharmacology and Disease Biology
Builds
Preclinical efficacy and PK/PD data for sustained-release drug candidates
Domain
Biotechnology, Obesity, Cardiometabolic diseases
Required skills
In vivo pharmacology strategy, disease model validation (mice, rats, NHP), CRO management, translational biology, data analysis, regulatory writing (IND submissions), PK/PD interpretation
Preferred skills
Experience building internal teams, program strategy, go/no-go decision making
Technologies
DEXA, qNMR, MRI, hydrogel-based microsphere technology
Responsibilities
Set strategic direction for in vivo pharmacology across the portfolio; Lead design and oversight of in vivo efficacy and PK/PD studies at CROs; Manage CRO partnerships and study execution; Validate disease-relevant animal models for obesity and metabolic disease; Translate in vitro and in vivo data to guide clinical development and human dose projections; Author preclinical sections of IND submissions.
Seniority
Director, Preclinical Leadership Team