Scientist I, Platform Innovation
Core
Establish a new platform innovation lab to develop transformative solutions in gene editing and cellular engineering, specifically targeted cargo integration in dividing and non-dividing cells. (via careerplan.io/jobs/cecf6f85-c6af-411b-b085-c87b078a1565-scientist-i-platform-innovation-at-basecamp-research)
Role type
Scientist I, Platform Innovation (hands-on IC)
Builds
Novel gene editing tools, plasmid libraries, and cloning workflows for therapeutic development
Domain
Biotech / Gene Editing / Cellular Engineering
Required skills
gene editing, NGS assay development, protein engineering, high-throughput cloning, mammalian cell culture, transfection, cell-line generation, DNA/RNA extraction, PCR, ddPCR, NGS library preparation, off-target analytics
Preferred skills
preclinical cell therapy program experience, flow cytometry, novel gene editing off-target analytics methods, mechanistic understanding of gene editing tools (nucleases, base editors, transposons, retrotransposons, recombinases), AI protein design integration, NGS instrumentation, basic bioinformatics
Responsibilities
Contribute to strategy for design, build, test cycles of novel protein enzymes; Build and screen plasmid libraries and develop cloning workflows; Quantify editing outcomes using ddPCR, qPCR, flow-cytometry and NGS readouts; Optimise hits for activity and specificity using human primary cells and cell lines; Establish strong documentation practices and lab SOPs as a founding member
Seniority
Individual Contributor (IC), Early Career (PhD/MSc level)