Process Chemistry Principal Scientist
Core
Lead the development, optimization, and scale-up of preparative chromatography methods (HPLC, SFC, IEX, SEC) and kilo-scale synthesis for drug substance manufacturing in both R&D and cGMP environments.
Role type
Principal Scientist (Process Chemistry & Preparative Separations)
Builds
Kilo-scale cGMP purification capabilities and laboratory infrastructure for new therapeutic modalities
Domain
Pharmaceutical manufacturing / Process Chemistry / Analytical Chemistry
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work -> physical/clinical work (specifically: kilo-scale synthesis and purification of drug substances)
Required skills
Preparative chromatography (HPLC, SFC, IP-RP, AEX, CEX, SEC), Large-scale synthesis (gram-to-kilogram), cGMP compliance, Method development, Troubleshooting complex separations, Lab infrastructure management, Cross-functional collaboration, Technical leadership, GMP documentation
Preferred skills
PhD in Chemistry/Chemical Engineering, Experience with oligonucleotide synthesis and purification, Experience with jacketed reactor operations, Experience with mass-directed purification systems
Technologies
Empower, OpenLab, Jacketed reactors, Large-scale reactor systems, Ultrafiltration/diafiltration equipment
Responsibilities
Lead preparative chromatography method development and scale-up; Execute and troubleshoot complex purification campaigns; Establish and maintain large-scale chromatography lab infrastructure; Perform kilo-scale synthesis of drug substance intermediates; Support scale-up and process chemistry collaboration; Build peptide and oligonucleotide purification capability; Mentor and develop scientific staff; Author and own GMP documentation; Lead cross-functional technical initiatives; Ensure GMP compliance, quality, and safety
Seniority
Principal, hands-on IC with strategic leadership
