Cell Models & Delivery Biology Principal Research Associate
Core
Develop, optimize, and apply advanced in vitro cellular models (2D, 3D, organoids) and execute cell-based assays to evaluate Lipid Nanoparticle (LNP) delivery, uptake, and pharmacological activity.
Role type
Principal Research Associate (LNP Delivery Biology)
Builds
In vitro cellular models and cell-based screening workflows for LNP discovery and optimization
Domain
Biotechnology / Drug Delivery / Cell Biology
Required skills
Cell culture (2D/3D, primary cells, organoids), Cell-based assay execution, Imaging technologies, Flow cytometry, Protein assays, Laboratory automation (liquid handlers), High throughput screening, IND-enabling studies, Data visualization, Electronic lab notebook management
Preferred skills
Receptor biology, Intracellular trafficking, LNP formulation/dosing, Culture of primary human epithelial cells (kidney, intestine, lung)
Responsibilities
Establish and optimize advanced cellular models; Execute and optimize automated cell-based assays; Characterize receptor biology and immunological responses; Troubleshoot assays and improve experimental workflows; Lead adoption of new automation workflows; Collaborate on experiment design for hit identification
Seniority
Principal, hands-on IC