Principal Scientist I, (QSP) - Modeling & Simultion
Core
Develop and apply mechanistic disease models (QSP, systems biology, PK/PD) to inform scientific decisions from discovery through early clinical development.
Role type
Principal Scientist, Quantitative Systems Pharmacology (QSP) Modeling
Builds
Predictive disease models and simulation outputs for target validation, biomarker understanding, and study design
Domain
Biopharmaceutical R&D, Quantitative Systems Pharmacology, Systems Biology
Deliverable
production ML models | product features
Required skills
ODE model construction, parameter estimation, data curation, PK/PD modeling, QSP modeling, mechanistic PBPK/PD modeling, MATLAB scripting, R scripting, data visualization
Preferred skills
Drug discovery, Translational medicine, Simulation software
Technologies
MATLAB, R, ODE solvers
Responsibilities
Develop mechanistic disease models integrating preclinical and clinical data; calibrate and qualify models; generate simulations to support decision-making; establish modeling workflows and best practices; communicate modeling insights to multidisciplinary teams.
Seniority
Senior, hands-on IC
