Principal Scientist II/Senior Principal Scientist, Modeling & Simulation (Dual Level Posting)
Core
Develop and apply mechanistic modeling approaches (PK/PD, QSP, PBPK/PD) to accelerate oligonucleotide therapeutics from discovery through clinical translation.
Role type
Principal Scientist II / Senior Principal Scientist (Modeling & Simulation)
Builds
Translational models linking drug pharmacology, tissue biodistribution, and mechanism of action for oligonucleotide therapeutics
Domain
Pharmaceutical industry, neuroscience and cardiovascular disease
Deliverable
production ML models
Required skills
ODE modeling, parameter estimation, data visualization, pharmacokinetics, pharmacodynamics, quantitative systems pharmacology, mechanistic PBPK/PD, scripting languages (MATLAB, R), integration of computational modeling and biological concepts
Preferred skills
Pharmacometrics (Population PK, exposure-response), oligonucleotide therapeutics (siRNA, ASO, PMO), antibody-drug conjugates (ADCs), neuroscience modeling, cardiovascular disease modeling
Technologies
MATLAB, R, agentic AI workflows
Responsibilities
Develop and execute modeling strategies to guide model-informed decisions from therapeutic design to first-in-human dose selection; Build and apply mechanistic models linking drug pharmacology and downstream effects; Integrate modeling into preclinical study design and interpretation; Collaboratively develop platform-level QSP and PBPK/PD models; Engage in strategic initiatives to create platform-level translational modeling strategies and develop modeling workflows
Seniority
Senior, hands-on IC
