Associate Director, Quantitative Systems Pharmacology
Core
Develop and apply mechanistic mathematical models (QSP) to guide clinical study designs and interpret results for oncology treatments.
Role type
Associate Director, Quantitative Systems Pharmacology (QSP) Expert
Builds
Mechanistic models of biological, physiological, and pathophysiological processes to evaluate disease pathways and drug candidates
Domain
Oncology, Biopharmaceutical R&D, Quantitative Systems Pharmacology
Deliverable
production ML models | product features
Required skills
PhD in Applied Mathematics/Engineering/Pharmaceutical Sciences, Mathematical modeling & simulation (ODEs, parameter estimation), Computational programming (MATLAB, R, Julia, C/C++), Quantitative clinical pharmacology tools (NONMEM, Simcyp, SAS), PK-PD modeling, Model verification & validation
Preferred skills
Drug development practices in oncology, Mathematical modeling guidelines
Technologies
MATLAB, R, Julia, SimBiology, C/C++, NONMEM, WINNONLIN, Simcyp, SAS
Responsibilities
Build QSP models to evaluate disease progression and drug modalities; Collaborate with biologists, clinicians, and pharmacometricians to inform R&D programs; Serve as QSP point-of-contact for project teams; Analyze complex data sets in context of disease mechanisms; Provide scientific expertise for clinical development decision-making; Establish verification & validation processes for QSP models; Advise on dose, regimen, and study design optimization.
Seniority
Senior, hands-on IC with strategic influence
