Senior Scientist Ⅱ, DSP( Preparative Purification )
Core
Design and implement scalable purification strategies for complex small molecules and ADC drug-linkers, supporting projects from early development through GMP manufacturing.
Role type
Senior Scientist II, Preparative Purification (Small Molecules & ADC Drug-Linkers)
Builds
Purified small molecules, ADC drug-linkers, payloads, and complex intermediates for pharmaceutical manufacturing
Domain
Pharmaceutical manufacturing / Process Chemistry
Required skills
Preparative HPLC method development and scale-up, Reverse-phase chromatography, Normal-phase chromatography, Column screening and loading optimization, Gradient development, Recovery improvement, Purification of highly functionalized small molecules, Separation of regioisomers and diastereomers, Process robustness and manufactability assessment, GMP manufacturing process transfer, Cost and productivity optimization
Preferred skills
ADC drug-linker development, Cytotoxic payload purification, Highly potent compound handling, Downstream process development, Technology transfer, Subject Matter Expert (SME) in isolation sciences
Technologies
Preparative HPLC, Reverse-phase chromatography, Normal-phase chromatography
Responsibilities
Develop preparative chromatography methods for small molecules and ADC drug-linkers, Optimize purification processes for multi-gram to kilogram-scale production, Transfer purification processes from lab to pilot and GMP manufacturing scale, Collaborate with Process Chemistry, Analytical Development, and Manufacturing teams, Troubleshoot impurity profiles and separation challenges
Seniority
Senior, hands-on IC
