Senior Scientist Ⅱ, DSP( Preparative Purification )
Core
Design and implement scalable purification strategies for complex small molecules and ADC drug-linkers, supporting projects from early development through GMP manufacturing.
Role type
Senior Scientist II, Preparative Purification (Small Molecules & ADC Drug-Linkers)
Builds
Purified intermediates, drug-linkers, and payloads for pharmaceutical manufacturing
Domain
Pharmaceutical manufacturing / Preparative chromatography
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Preparative HPLC method development, Reverse-phase chromatography, Normal-phase chromatography, Column screening, Loading optimization, Gradient development, Recovery improvement, Process scale-up (lab to GMP), Impurity separation (regioisomers, diastereomers), Cost and productivity optimization
Preferred skills
ADC drug-linker purification, Cytotoxic payload handling, GMP technology transfer, Subject Matter Expert (SME) in isolation sciences
Technologies
Preparative HPLC, Reverse-phase systems, Normal-phase systems
Responsibilities
Develop preparative chromatography methods for small molecules and ADC components, Optimize purification processes for multi-gram to kilogram scale, Transfer processes from lab to pilot and GMP manufacturing, Collaborate with Process Chemistry and Manufacturing teams
Seniority
Senior, hands-on IC
