Lead Scientist I（Purification）
Core
Lead purification science and chromatographic technology development for complex molecules including small molecules, oligonucleotides, ADCs, and PROTACs from discovery through scale-up.
Role type
Senior IC Lead Scientist (Purification)
Builds
Scalable chromatographic purification processes and strategies for drug development programs
Domain
Pharmaceutical R&D / Biopharmaceutical Manufacturing
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Chromatographic method development, Process optimization, Scale-up, Modeling of complex molecules, Technology transfer, Root-cause analysis, Strategy design
Preferred skills
ADC payload/linker purification, Peptide/oligonucleotide purification, Highly potent compound handling, Commercial manufacturing support, Automation implementation
Technologies
Preparative HPLC, Ion-exchange chromatography, Chiral chromatography, Flash chromatography, Modeling tools
Responsibilities
Design and optimize purification processes for complex molecules, Develop scalable chromatographic solutions from mg to kg quantities, Collaborate with chemists to establish purification best practices, Mentor junior scientists on purification expertise, Evaluate emerging purification technologies and automation solutions, Present scientific findings to internal and external forums
Seniority
Senior, hands-on IC with technical leadership
