Senior Scientist, DMPK (Small Molecule and/or Large Molecule)
Core
Conduct in vitro and in vivo metabolite identification and structural characterization for small and large molecule therapeutics using LC-MS/MS and radioanalysis.
Role type
Senior Scientist, Drug Metabolism and Pharmacokinetics (DMPK)
Builds
Preclinical ADME data and metabolite identification reports for discovery and development projects
Domain
Biopharmaceuticals, Drug Metabolism, Analytical Chemistry
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
enzymology, LC-MS/MS methodology, biotransformation of small and large molecules, radioanalysis, NMR, sample preparation, data interpretation
Preferred skills
isolation of metabolites, NMR, industrial discovery and development experience
Technologies
LC-MS/MS, NMR, radioanalysis (14C, 3H)
Responsibilities
Prepare and analyze samples for LC-MS/MS, develop and optimize MS methods, perform radioanalysis and radio-profiling, troubleshoot analytical issues, write protocols and reports, present results to leadership
Seniority
Senior, hands-on IC
