Senior Principal Scientist, Bispecifics & Antibody Engineering
Core
Lead a small team to design, engineer, and optimize next-generation bispecific and multispecific antibody therapeutics using structural insight, AI/ML-enabled design, and high-throughput experimental validation.
Role type
Senior Principal Scientist (Bispecific Antibody Engineering)
Builds
Novel bispecific and multispecific antibody formats for oncology, immunology, and infectious disease
Domain
Biopharmaceuticals / Structural Biology / Protein Engineering
Deliverable
production ML models | product features
Required skills
Structural biology, protein engineering, bispecific/multispecific antibody design, molecular cloning, protein expression, purification, biophysical characterization, cell-based assay development, team leadership, AI/ML integration
Preferred skills
Computational design, automated high-throughput protein engineering workflows
Technologies
AlphaFold, Rosetta, MOE, PyMOL
Responsibilities
Set molecular design strategy, lead structure-guided design of novel formats, drive protein engineering campaigns integrating AI/ML, oversee high-throughput construct generation and characterization, build curated engineering datasets, lead and mentor a team of scientists
Seniority
Principal, hands-on IC with people management
