Associate Principal Scientist, Pharmacokinetics
Core
Lead the design and interpretation of in silico, in vitro, and in vivo analyses to support the discovery and clinical development of therapeutics, focusing on DMPK properties, PK/PD, and DDI risk.
Role type
Associate Principal Scientist (Drug Metabolism and Pharmacokinetics)
Builds
Preclinical and clinical development programs for small molecule and biologics therapeutics
Domain
Pharmaceutical R&D / Drug Discovery and Development
Required skills
DMPK, Pharmacokinetics/Pharmacodynamics (PK/PD), Drug Interaction (DDI) Risk Assessment, Translational Modeling, Regulatory Document Authoring, Preclinical Study Design, PBPK Modeling, Bioanalytical Techniques, LC-MS, Immunoassays
Preferred skills
PBPK Modeling Software (SimCYP, Phoenix), Mentoring Junior Staff, Publication Track Record
Technologies
SimCYP, Phoenix, LC-MS
Responsibilities
Guide the design and interpretation of in silico, in vitro, and in vivo analyses; Assess DDI risk using static mechanistic and physiologically based pharmacokinetic (PBPK) models; Author source reports and documents for regulatory filings (IB, IND, WMA); Evaluate and predict program risks to ensure efficient progression.
Seniority
Senior, hands-on IC with leadership responsibilities