Senior Scientist, Pharmacokinetics
Core
Design and execute LC-MS methods to characterize drug metabolism and pharmacokinetic (DMPK) properties of peptides, protein therapeutics, and drug conjugates from discovery through early development.
Role type
Senior Scientist, Pharmacokinetics (DMPK)
Builds
Bioanalytical workflows and data for candidate selection in drug discovery
Domain
Pharmaceutical R&D, Bioanalysis, Mass Spectrometry
Required skills
LC/MS method development, High Resolution Mass Spectrometry (HRMS), Chromatographic separation, Therapeutic protein analysis, Macrocyclic peptide analysis, Monoclonal antibody analysis, Drug conjugate analysis, In vitro matrix characterization
Preferred skills
DMPK experimental design, Electronic Lab Notebook (ELN), In vivo analysis, Publication track record
Technologies
LC-MS, HRMS, Mass Spectrometers
Responsibilities
Develop and validate LC-MS methods for therapeutic antibodies and peptides; Lead automation-enabled discovery workflows; Characterize large molecule drug properties in in vitro matrices; Collaborate with cross-site PDMB experts to optimize drug candidates
Seniority
Senior, hands-on IC
