Associate Principal Scientist, Upstream Process Development
Core
Develop high-yield, robust, and scalable cell culture processes for biologics to support clinical trials and commercial manufacturing.
Role type
Associate Principal Scientist, Upstream Process Development
Builds
Cell culture processes for biologics pipeline
Domain
Biologics / Biopharmaceuticals
Required skills
Mammalian cell culture, fed-batch processes, CHO cell biology, bioreactor scale-up, statistical design of experiments, process characterization, regulatory filing, cross-functional collaboration, mentoring
Preferred skills
Cell culture media development, high-throughput microbioreactors, perfusion process development, metabolic flux analysis, omics, machine learning, computational fluid dynamics, technology transfer
Technologies
SIMCA, JMP, Bioreactor simulation and modeling
Responsibilities
Lead upstream process development for first-in-human and commercial processes; execute process characterization and regulatory filings; partner with Manufacturing and Analytical Sciences to achieve quality by design; drive process improvement initiatives; collaborate with academia and vendors on new technologies; publish and patent process innovations
Seniority
Senior, hands-on IC with mentorship responsibilities
