Senior Director, Advanced Pharmacometrics, Quantitative Pharmacology and Pharmacometrics – Immuno-Oncology (Hybrid or Remote)
Core
Lead quantitative pharmacology strategy and advanced pharmacometrics modeling for oncology drug development from candidate nomination through registration.
Role type
Senior Director, Advanced Pharmacometrics (Strategy & Technical Leadership)
Builds
Model-informed drug development (MIDD) strategies, regulatory-grade pharmacometric deliverables, and clinical trial designs for oncology assets.
Domain
Biopharmaceuticals, Oncology, Clinical Development
Deliverable
production ML models | dashboards & analysis | client delivery
Required skills
Population PK/PD, tumor dynamics and survival modeling, Bayesian inference, model-based meta-analysis (MBMA), advanced clinical trial simulation, integrating PROs and RWD into NLME, oncology biology understanding, therapeutic modality expertise (ADCs, TCEs, mAbs, small molecules)
Preferred skills
AI/ML integration in pharmacometrics, hierarchical and joint modeling, multiple therapeutic areas
Technologies
NONMEM, Pumas, Stan, R, Bayesian platforms
Responsibilities
Lead quantitative pharmacology strategy across the oncology portfolio; Develop long-range plans for integrating MIDD and Bayesian modeling; Oversee development of advanced pharmacometrics modeling for dose selection and benefit-risk assessments; Lead, mentor, and develop a team of quantitative scientists; Collaborate with Translational, Clinical, and Biostatistics functions to integrate modeling into decision frameworks; Contribute to regulatory strategy through pharmacometric reports and presentations.
Seniority
Senior Director, strategic leadership with hands-on technical oversight
