CareerPlan

Process modeling (Protein/Antigen) Principal Data Scientist

Waltham, MA, USFull-time$122k–$177k2026-10-27 → 2026-11-13
Based in United States

Core

Lead the development and deployment of AI, machine learning, mechanistic, and hybrid modeling solutions to accelerate recombinant protein vaccine process development and manufacturing.

Role type

Principal Data Scientist (Process Modeling)

Builds

Digital twins, simulation tools, and decision-support frameworks for vaccine manufacturing

Domain

Biopharmaceuticals / Vaccine R&D / Process Engineering

Deliverable

production ML models

Required skills

AI, machine learning, mechanistic modeling, hybrid modeling, multivariate data analysis, Bayesian optimization, Design of Experiments, Python, R, MATLAB, gPROMS

Preferred skills

Digital twins, process simulation, CHO cell culture modeling, protein purification optimization, cell line development modeling

Technologies

Python, R, MATLAB, JMP, gPROMS, GoSilico

Responsibilities

Lead development of AI/ML and hybrid modeling solutions for vaccine manufacturing; Apply advanced analytics to identify critical process parameters and optimize yield; Develop modeling solutions for upstream processes (CHO, baculovirus); Support optimization of downstream purification operations; Build and deploy digital twins and simulation tools; Provide scientific leadership and mentorship in data science and process modeling.

Seniority

Principal, hands-on IC with mentorship