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Clinical Lead Early Clinical and Experimental Therapeutics

Cambridge, MA, US💼 Full-time🗓 2026-09-21 → 2026-09-25

Core

Lead early clinical development (Phase 1a/b, 2a) and experimental therapeutics studies to validate human targets and support Go/No-Go decisions for novel modalities including small molecules, antibodies, peptides, and gene therapies.

Role type

Senior Clinical Lead / Study Medical Manager (SMM)

Builds

First-in-human studies, natural history studies, mechanistic trials, and early clinical development plans

Domain

Biopharmaceutical R&D, Translational Medicine, Early Clinical Development

Deliverable

production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work

Required skills

early clinical trial design, dose selection, safety monitoring, protocol development, regulatory document authoring, cross-functional team leadership, data interpretation, Go/No-Go decision making

Preferred skills

translational research mindset, broad biomedical knowledge, laboratory research experience, late-phase clinical trial experience

Technologies

none stated

Responsibilities

Design early development plans and First-In-Human studies; supervise study execution and medical monitoring; review and interpret clinical data; author clinical protocols, reports, and regulatory documents; lead dose escalation meetings; ensure compliance with clinical trial standards; present data to internal and external stakeholders

Seniority

Senior, hands-on IC with study management authority

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