Senior Medical Director, Translational Medicine & Early Clinical Development
Core
Lead early development and mechanistic clinical studies for metabolic liver and cardiometabolic therapeutics, integrating clinical and biomarker data to inform go/no-go decisions and label strategy.
Role type
Senior physician-scientist medical director (translational medicine & early clinical development)
Builds
First-in-human and early proof-of-concept studies (mechanistic, indication-expansion) for MASH and cardiometabolic conditions
Domain
Biopharmaceuticals, metabolic liver disease (MASH), cardiometabolic disease
Required skills
Clinical trial leadership (FIH/PoC), translational medicine strategy, biomarker integration, cross-functional team leadership, regulatory interaction, scientific communication
Preferred skills
Hepatology/gastroenterology/endocrinology/cardiology background, metabolic liver or cardiometabolic disease experience, regulatory agency interaction
Technologies
None stated
Responsibilities
Serve as global medical lead/monitor for early phase studies; Lead design of study concepts and protocols; Provide ongoing medical oversight of trials; Define and own translational strategy from preclinical to late-stage; Chair early asset teams/translational working groups; Present program work to Executive Team and Board; Mentor junior physicians and PhD scientists
Seniority
Senior, hands-on IC with leadership responsibilities