Senior Associate Scientist Purification Process Development
Core
Design and optimize viral vector purification processes (AAV and non-viral) for high-dose gene therapy programs, supporting scale-up and technology transfer.
Role type
Senior Associate Scientist (Downstream Process Development)
Builds
Robust and efficient purification processes for viral vectors
Domain
Biopharma / Gene Therapy / Viral Vector Manufacturing
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Viral vector purification (AAV/non-viral), Column chromatography, Depth filtration, Tangential flow filtration (TFF), UF/DF, Virus clearance/inactivation, Scale-up manufacturing, Technology transfer, Process optimization, DOE, Technical report writing
Preferred skills
Spectrophotometry, ELISA, HPLC, SDS-PAGE, Quality by Design, Large-scale unit operations, Process gap analysis, Risk assessment, Biosafety Level 2 lab experience
Technologies
AKTA, Automated protein purification chromatography
Responsibilities
Develop and conduct viral vector purification experiments to increase yield; Maintain advanced knowledge of chromatography principles and separation methods; Lead study design and optimization of purification process conditions; Perform troubleshooting experiments and communicate findings; Support scale-up activities to implement manufacturing processes; Communicate with internal teams and external CDMOs for tech transfer; Contribute to manuscript and patent writing
Seniority
Mid-level, hands-on IC