Principal Scientist, Early Pipeline Development
Core
Lead downstream purification process development for next-generation AAV gene therapy, focusing on developability of lead candidates and new platform processes for novel capsids and cargo vectors.
Role type
Principal Scientist I/II (Bioprocessing)
Builds
Downstream purification processes for AAV gene therapy vectors
Domain
Biotechnology / Gene Therapy / AAV manufacturing
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
AAV gene therapy manufacturing, downstream purification (affinity/ion-exchange chromatography), AKTA purification systems, people management, process development strategy, cross-functional collaboration
Preferred skills
Viral gene therapy experience, Technical Research & Development partnership
Technologies
AKTA purification systems
Responsibilities
Lead and manage a 3-5 person downstream process team, coordinate activities with upstream and analytical teams, develop strategies for early drug discovery and developability assessment, transfer manufacturing knowledge to R&D, manage project workflows, prepare technical documentation
Seniority
Principal, hands-on IC with people management