Principal Scientist, Lab Head, Integrative Neuroscience
Core
Lead a multidisciplinary team to develop novel RNA-based therapeutics for neurological disorders, specifically neuropsychiatric, neurodevelopmental, and seizure-related conditions.
Role type
Principal Scientist, Lab Head
Builds
Novel therapeutics (siRNA, antisense oligonucleotides) for neurological diseases
Domain
Biopharma / Integrative Neuroscience / RNA therapeutics
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
RNA-based therapeutic modalities (siRNA, ASOs), drug development pipeline management, in vitro and in vivo model establishment, human dataset interrogation, genetic and genomic approaches, AI application in screening and analysis, iPSC-derived neuronal systems, in vivo pharmacology in rodents/NHPs
Preferred skills
Neuropsychiatry and/or developmental disorders expertise, ion channel biology, scientific creativity with impactful publications, complex co-culture models
Technologies
siRNA, antisense oligonucleotides (ASOs), iPSC-derived systems, AI-based screening platforms
Responsibilities
Lead drug development programs by managing timelines and defining scientific questions; Establish in vitro and in vivo models for molecule testing and biomarker discovery; Interrogate human datasets to identify novel pathways and targets; Mentor team members and support laboratory execution; Implement AI into experimental and analysis workflows; Build and maintain external scientific networks for collaborations and licensing; Publish scientific findings in peer-reviewed journals and present at conferences
Seniority
Principal, hands-on IC with strategic leadership