Senior Principal Scientist
Core
Spearhead execution and expansion of mast cell disorders Research & Development pipeline, providing deep expertise in hematopoietic stem cell biology for rare immune and hematologic conditions.
Role type
Senior Principal Scientist (Rare Disease Immunology)
Builds
First-in-class and best-in-class rare disease therapeutics for mast cell disorders and related immune conditions.
Domain
Biopharmaceuticals, Rare Diseases, Hematology, Immunology
Deliverable
Research | client delivery
Required skills
Hematopoietic stem cell biology, Mast cell disorder research, Early and late-stage research strategy, Preclinical program leadership, Cross-portfolio synergy identification, Strategic partnership development, Regulatory document drafting (IND/CTA), CRO study management, Therapeutic modality knowledge (biologics, small molecules, genomic medicines), Computational biology and omics familiarity.
Preferred skills
Scientific publications and external visibility, Translational research experience, Network of research and clinician colleagues, Cell-based and animal model expertise, Experience managing studies at CROs.
Technologies
Broad range of cell-based and animal models, Biologics, Small molecules, Genomic medicines, Computational biology tools, Omics platforms.
Responsibilities
Serve as subject matter expert for mast cell disorders and related rare immune conditions; Direct target identification and mechanistic biology research; Initiate and lead new preclinical programs; Identify cross-portfolio synergies with rare blood disorders; Monitor competitive landscape and establish strategic partnerships; Partner with Clinical and Business Development teams for portfolio development; Contribute to organizational excellence through strategic planning and regulatory submissions.
Seniority
Principal, strategic leadership & hands-on research
