Principal Scientist Mass Spectrometry Lab
Core
Lead the mass spectrometry laboratory in Montpellier to support CMC analytical development teams, focusing on structural characterization and quantitation of mutagenic/nitrosamine impurities using HPLC/HRMS and GC/MS.
Role type
Principal Scientist / Mass Spectrometry Lab Manager
Builds
Structural characterization data and validated quantitation methods for synthetic small molecules (APIs, impurities, degradants) in CMC projects.
Domain
Biopharma / Analytical Chemistry / Mass Spectrometry
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
High-resolution mass spectrometry expertise, HPLC/HRMS and GC/MS method development, fragmentation mass spectra interpretation, GMP and regulatory knowledge (ICH, Pharmacopoeia), team management, project leadership
Preferred skills
Experience with Orbitrap, QTof, Triple Quad instruments, MassLyns, Xcalibur, Chromeleon software, automation implementation, scientific publications and patents
Technologies
Orbitrap, QTof, Triple Quad, MassLyns, Xcalibur, Chromeleon, HPLC, HRMS, GC/MS
Responsibilities
Manage laboratory resources and equipment maintenance, define and implement nitrosamine/mutagenic impurity strategies, author regulatory documentation and participate in audits, collaborate with CMC teams to solve analytical problems, lead projects as Analytical Team lead
Seniority
Principal, hands-on IC with management responsibilities
