Sr. Director, Translational Medicine Lead, Autoimmune
Core
Lead translational strategy for high-priority autoimmune programs and shape cross-program strategy for Moderna's Immune Therapeutics portfolio.
Role type
Senior Director, Translational Medicine Lead (Autoimmune)
Builds
Coherent development strategies for clinical-stage immune-mediated assets
Domain
Biotechnology / Autoimmune Immunology / Translational Medicine
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
human autoimmune immunology, translational drug development, immune tolerance, pathogenic T- and B-cell biology, immune-cell depletion and reprogramming, clinical biomarkers, quantitative pharmacology, mechanism-based development
Preferred skills
antigen-specific tolerance, Treg biology, B-cell depletion, immune-cell engineering/reprogramming, first-in-human development of novel immunomodulatory therapies, mRNA therapeutics, lipid nanoparticle delivery
Technologies
high-dimensional flow cytometry, antigen-specific functional assays, immune repertoire analysis, transcriptomics, proteomics, serology, HLA/genetic analysis, tissue-based approaches
Responsibilities
Lead clinical-facing translational strategy for multiple autoimmune assets; Define evidence requirements for mechanism and therapeutic window; Shape autoimmune portfolio and modality strategy; Provide senior leadership in human translational immunology; Advance cross-program biomarker and translational technology strategy; Partner with Clinical and Quantitative Pharmacology to establish PK/PD frameworks; Shape translational safety strategy; Serve as senior translational voice in program and portfolio governance; Lead cross-program reverse translation; Build scientific capability and talent; Lead external scientific engagement
Seniority
Senior Director, strategic leadership & mentorship
