Sr. Scientist, Antibody Discovery and Engineering
Core
Senior Scientist leading experimental protein and antibody engineering workstreams to discover and optimize antibody-based therapeutics for oncology and autoimmune diseases.
Role type
Senior hands-on IC antibody discovery and engineering scientist
Builds
Novel antibody therapeutics (IgG, Fab, scFv, bispecifics, T cell engagers, etc.) for oncology and autoimmune indications
Domain
Biopharmaceuticals / Antibody Discovery / Protein Engineering
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Yeast surface display, antibody/protein engineering, molecular biology, library design, FACS-based selection, affinity maturation, NGS data analysis, protein characterization (Biacore, ELISA, flow cytometry), cloning, mutagenesis, construct design
Preferred skills
Advanced yeast/mammalian display, AI/ML-enabled protein design, engineering advanced formats (ADCs, CAR-T), immunization-based discovery, cell-based functional assays
Technologies
FACS, Biacore, Carterra, Octet, NGS, ELISA, MSD, flow cytometry
Responsibilities
Design and execute yeast display workflows for library construction and selection; translate computational design hypotheses into testable constructs; characterize candidates for binding, specificity, and developability; analyze sequence and functional data to nominate leads; troubleshoot complex experiments and optimize engineering methods
Seniority
Senior, hands-on IC
