Sr. Director, Head, Quantitative Systems Pharmacology
Core
Strategic leader for mechanistic modeling, systems biology, and model-informed drug development (MIDD) to accelerate early development decisions and optimize dose/schedule strategies.
Role type
Senior Director, Head of Quantitative Systems Pharmacology
Builds
Mechanistic models (disease progression, target engagement, immune dynamics) and integrated quantitative strategies for drug development.
Domain
Biopharma / mRNA therapeutics / Systems Pharmacology
Deliverable
production ML models
Required skills
mechanistic modeling, systems biology, PK/PD, biomarker integration, regulatory filing strategy, cross-functional leadership, scientific mentoring, MATLAB/SimBiology, Monolix, R, Python
Preferred skills
mRNA/novel modalities experience, PBPK modeling, virtual populations, digital-twin simulation, infrastructure/toolchain development, scientific publications
Technologies
MATLAB/SimBiology, Monolix, R, Python
Responsibilities
Develop and implement QSP strategy across therapeutic areas; Lead design and application of multi-scale mechanistic models; Collaborate with Clinical Pharmacology, Translational Medicine, and DMPK to design integrated strategies; Provide QSP input for INDs, IBs, and regulatory filings; Represent Moderna in global scientific forums and regulatory workshops.
Seniority
Senior Director, strategic leadership with hands-on scientific oversight
