Senior Scientist, Spatial Assays
Core
Lead the strategy, design, development, optimization, qualification, validation, transfer, implementation, and lifecycle management of tissue-based biomarker assays (IHC, ISH, mIF, spatial/digital pathology) to support translational research and clinical development of engineered cell-based therapies.
Role type
Senior Scientist, Spatial Assays (Translational Research)
Builds
Tissue-based biomarker assays and novel pathology methodologies for cell therapy programs
Domain
Biotechnology / Oncology / Cell Therapy / Spatial Biology
Required skills
assay development and validation, multiplex immunofluorescence (mIF), image analysis, spatial biology, CRO management, project management, biomarker data interpretation, tissue processing, antibody characterization
Preferred skills
Ph.D. in Pathology/Immunology/Cancer Biology, expertise in CosMx/COMET/GeoMx/RNAscope platforms, experience in oncology/immunology/autoimmune disease, digital pathology, flow cytometry
Technologies
CosMx, COMET, GeoMx, RNAscope, Akoya, 10xgenomics, digital pathology platforms, image analysis software
Responsibilities
Lead assay feasibility studies and orthogonal specificity assessments; Serve as SME for external laboratory partnerships and assay transfer; Establish assay performance criteria and quality control measures; Partner with translational scientists to develop fit-for-purpose biomarker strategies; Interpret and communicate assay validation data to multidisciplinary teams; Manage complex external collaborations and vendor relationships; Drive innovation by implementing emerging spatial imaging technologies
Seniority
Senior, hands-on IC