Senior Principal Scientist, Molecular Assays & Genomics Team Lead (Cell Therapy Translational Research)
Core
Lead the Molecular Assays & Genomics team to develop and implement molecular biomarker assays supporting translational research, clinical development, and patient-safety assessments for cell and gene therapy programs.
Role type
Senior Principal Scientist, Molecular Assays & Genomics Team Lead
Builds
Molecular biomarker assays for cell and gene therapy programs
Domain
Biotechnology / Cell Therapy / Genomics
Required skills
Molecular biology, Genomics, Assay development and validation, Next-generation sequencing, ddPCR, RT-qPCR, Team leadership, Scientific strategy, Clinical implementation, Laboratory management
Preferred skills
Cell and gene therapy experience, Vector or transgene detection, Clonality assessment, CAP/CLIA/GLP laboratory experience, TCR sequencing, Whole-genome sequencing
Technologies
ddPCR, Next-generation sequencing, RT-qPCR, Whole-genome sequencing, TCR sequencing
Responsibilities
Lead the Molecular Assays & Genomics team providing scientific direction and people leadership; Serve as subject matter expert for molecular and genomic testing; Translate translational questions into fit-for-purpose assay approaches; Lead assay development, qualification, validation, transfer, and clinical implementation; Provide technical leadership across qPCR, NGS, and gene-expression profiling; Partner with Translational Program Leads to align assessments with objectives; Provide scientific oversight of assay design and data quality; Evaluate internal and external laboratory capabilities; Lead molecular testing for cellular persistence, pharmacodynamics, and safety events; Assess and advance new molecular technologies; Represent the function to cross-functional stakeholders.
Seniority
Senior Principal, hands-on IC with leadership