Principal Scientist, Discovery BioSciences Genomics, Oncology TRC
Core
Lead multi-omics research (genomics, functional genomics, spatial transcriptomics) to identify and validate oncology drug targets and decipher mechanisms of action.
Role type
Principal Scientist, Discovery BioSciences Genomics
Builds
Novel oncology therapeutics and target validation programs
Domain
Oncology / Genomics / Drug Discovery
Required skills
Single-cell RNA-seq, Spatial transcriptomics, NGS workflows, CRISPR screening, Wet lab experimental design, Molecular biology assays, Data analysis, Project management
Preferred skills
10x Visium HD, Bruker CosMx, 10x Xenium, WGS, WES, qPCR, dPCR, Organoid culture, Flow cytometry, FACS, Bioinformatics, AI/ML for genomics
Technologies
10x Genomics, Bruker, GraphPad Prism, FlowJo, Jira, LIMS, Confluence
Responsibilities
Conduct full-time laboratory-based research for target identification; Design and optimize genomics and functional assays; Execute novel genomic assays (scRNA-seq, spatial transcriptomics); Manage cross-functional research projects; Run and supervise NGS workflows; Train team members and maintain documentation.
Seniority
Principal, hands-on IC with strategic oversight