Scientist, Purification, RNA Process Development
Core
Designing efficient, robust, and scalable manufacturing processes for RNA drug substances (circular and linear mRNA) to improve yield, quality, and robustness.
Role type
Scientist, RNA Process Development (Purification)
Builds
RNA drug substance purification processes for clinical manufacturing
Domain
Biopharmaceuticals / mRNA therapeutics
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
chromatography, filtration (TFF/UF-DF), statistical design of experiments (DoE), process analytics, biophysical characterization (HPLC, CE, gel electrophoresis), cGMP/ICH/QbD principles, clinical manufacturing support
Preferred skills
advanced mathematics, nucleic acid chemistry, lipid chemistry, biology, scale down models, mechanistic models
Technologies
HPLC, CE, gel electrophoresis, automated experimental setups
Responsibilities
Design and execute experiments using DoE and statistical modeling; define purification process parameters and design space; collaborate with analytical and upstream teams; prepare technical reports; participate in tech transfer to GMP sites
Seniority
Mid-level Scientist (BS 6+ years, MS 4-6 years, PhD 0-2 years)