Principal Scientist, Cell Therapy Translational Biology Research
Core
Lead laboratory-based translational biology research for clinical-stage cell therapy assets in oncology and autoimmune indications to inform clinical strategy and regulatory decisions.
Role type
Principal Scientist, Translational Biology (Cell Therapy)
Builds
Non-clinical/translational data packages, novel in vitro assays, and regulatory documentation for cell therapy programs.
Domain
Biopharmaceuticals, Cell Therapy, Oncology, Autoimmune Disease
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Experimental design and execution, Mechanism of action studies, Drug combination studies, Biomarker identification, Patient stratification, Pharmacodynamic evaluation, In vitro assay development, Flow cytometry, Cell culture and imaging, High content data analysis (transcriptomic/proteomic), Electronic Lab Notebook (ELN) management, Regulatory document writing
Preferred skills
Immunology expertise, Oncology/Autoimmune disease knowledge, Drug development lifecycle experience, Incucyte/JMP/GraphPad Prism proficiency
Technologies
Incucyte, JMP, GraphPad Prism, ELN
Responsibilities
Develop and lead focused research projects with independent judgment; Design and lead non-clinical data packages for regulatory submissions; Contribute to biomarker strategy and patient stratification; Investigate manufacturing process impacts on product comparability; Mentor junior scientists; Present data at cross-functional meetings and contribute to manuscripts/patents.
Seniority
Principal, hands-on IC with mentorship responsibilities